Mechanism of action of cefoxitin is:

Cefoxitin is a second-generation cephamycin beta-lactam antibiotic active against a broad spectrum of Gram-positive and Gram-negative bacteria, as well as anaerobes. It exerts its bactericidal effect by targeting and covalently binding to penicillin-binding proteins (PBPs) located on the inner bacterial cytoplasmic membrane. This binding specifically inhibits the transpeptidase enzyme, which is responsible for catalyzing the cross-linking of peptidoglycan chains essential for cell wall structural integrity. The resulting disruption of cell wall synthesis compromises bacterial cell wall stability, leading to cell lysis and bacterial death under osmotic pressure. Its chemical structure with a 7-alpha-methoxy group imparts high resistance to cleavage by bacterial beta-lactamases.

A. Monoamine reuptake inhibitors increase synaptic monoamine levels and describe antidepressants like SSRIs/SNRIs, not beta-lactam antibiotics like cefoxitin.
B. Inhibitors of cholesterol synthesis describe HMG-CoA reductase inhibitors (statins), which lower systemic lipid levels rather than target bacterial cell walls.
C. GPIIb/IIIa inhibitors prevent platelet aggregation and activation, which is the mechanism of antiplatelet drugs like abciximab and eptifibatide.
E. Na-K-2Cl transporter inhibitors act on the thick ascending limb of Henle's loop in the kidney, which is the mechanism of loop diuretics like furosemide.

- Brunton, L. L., Hilal-Dandan, R., & Knollmann, B. C. (2018). Goodman & Gilman's: The Pharmacological Basis of Therapeutics (13th ed.). McGraw-Hill, Chapter 55: Penicillins, Cephalosporins, and Other β-Lactam Antibiotics, pp. 1023-1038.

- PubChem Compound Summary for CID 441022, Cefoxitin. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/441022