Hormonal agents are used to treat some cancers. An example is:

Hormonal therapy is a major pharmacological modality in clinical oncology used to treat specific hormone-sensitive neoplasms. Estrogen receptor-positive breast cancer cells strictly depend on circulating estrogen for their growth, division, and tumor progression. Estrogen antagonists, such as selective estrogen receptor modulators (e.g., tamoxifen) or pure antiestrogens (e.g., fulvestrant), bind to estrogen receptors on malignant cells and competitively inhibit estrogenic action, thereby depriving hormone-dependent tumors of the vital growth signals required for cell proliferation and survival. Selective estrogen antagonists represent a primary systemic treatment strategy for managing both early-stage and advanced hormone-receptor-positive breast carcinoma in clinical practice.

A. Thyroxine is hormone replacement therapy following thyroidectomy, not a direct hormonal antineoplastic agent used to suppress or treat thyroid cancer cells.

B. ACTH stimulates adrenal cortex steroidogenesis and cell growth, which would exacerbate rather than treat an adrenal cortex carcinoma.

D. Glucagon raises blood glucose levels and is not an antineoplastic hormonal therapy used to treat pancreatic carcinoma.

1. National Cancer Institute (NCI). Hormone Therapy for Cancer. National Institutes of Health. https://www.cancer.gov/about-cancer/treatment/types/hormone-therapy

2. Jordan, V. C. (2003). Tamoxifen: A most unlikely pioneering medicine. Nature Reviews Drug Discovery, 2(3), 205–213. DOI: https://doi.org/10.1038/nrd1031

3. Stanford Medicine Cancer Center. Hormone Therapy for Breast Cancer. Stanford Health Care Courseware & Patient Care Guides. https://stanfordhealthcare.org/medical-treatments/h/hormone-therapy-breast-cancer.html