Which disease is a malignancy of the lymphatic system?

Malignancies that originate in lymphatic tissue are collectively termed lymphomas (e.g., Hodgkin lymphoma, non-Hodgkin lymphoma). They are classified in ICD-10-CM under C81–C86 “Malignant neoplasms of lymphoid, hematopoietic and related tissue.” None of the other listed conditions involve malignant transformation; therefore, the only option that can correspond to a lymphatic malignancy is choice B.

A. Cystic fibrosis – Autosomal-recessive exocrine gland disorder of lung / pancreas; not a neoplasm.
C. Neutropenia – Quantitative deficiency of neutrophils; descriptive hematologic finding, not cancer.
D. von Willebrand’s disease – Inherited deficiency/dysfunction of von Willebrand factor causing bleeding tendency, not malignant.

1. ICD-10-CM Official Guidelines for Coding and Reporting

2024

Ch. 2 “Neoplasms

” Section C81–C86.

2. Sayles

N. & Foltz-Gibbons

L. Health Information Management Technology: An Applied Approach

6th ed.

AHIMA Press

2020

Ch. 5

pp. 153-154 (classification of lymphomas).

3. Swerdlow

S. H. et al. “The 2016 revision of the WHO classification of lymphoid neoplasms.” Blood

127(20)

2375-2390. https://doi.org/10.1182/blood-2016-01-643569

4. SEER Training Modules

National Cancer Institute. “Non-Hodgkin Lymphoma – Overview

” Section 1

para 2 (accessed 2025-10-07).