Which statements are true after enabling Multiple Shipping Routes? (Choose two.)

When the Multiple Shipping Routes (MSR) feature is enabled, it fundamentally changes how shipping is handled on a sales order, moving it from the header level to a more granular level. NetSuite groups line items by their designated "Ship To" address, creating distinct shipping routes.
(D) is correct because for each route (i.e., all items going to the same destination address on a single order), you can only select one shipping method. This is a key constraint of the feature.
(E) is correct because the shipping cost is no longer a single amount for the entire order. Instead, a shipping cost is calculated and applied for each route. This allows for charging shipping costs at a granular level, which is effectively "per line" or per group of lines.

A. You can use different Shipping Methods per line. This statement is a consequence of the feature but is less precise than (D). The method is assigned to the route (a group of lines), not directly to an individual line.
B. You can only use one Shipping Method. This is incorrect. The primary purpose of the feature is to allow multiple shipping methods on a single transaction, one for each destination address.
C. You can charge shipping to multiple account numbers. This describes Third-Party Billing, which is a separate NetSuite feature and not a direct function of enabling Multiple Shipping Routes.

1. NetSuite Help Center, SuiteAnswers, ID: 9997, "Enabling Multiple Shipping Routes."

This document states: "On the Shipping subtab of a sales order... NetSuite groups line items with the same shipping address together. For each group of items, you can select a shipping method and the shipping cost is calculated." This supports both correct answers: the selection of one method per group/location (D) and the calculation of cost per group/route (E).

2. NetSuite Help Center, "Shipping Items to Multiple Addresses."

This guide details the process: "When you use Multiple Shipping Routes, the shipping cost is calculated for each shipping address. The total shipping cost for the order is the sum of the shipping costs for each address." This directly supports the concept of charging shipping costs at a more granular level than the header (E). It also reinforces that the method is selected "For each address," which aligns with the constraint described in (D).